LOC100856461 protein (Canis lupus familiaris)

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Score

LOC100856461

Bromo domain-containing protein. (653 aa)

Predicted Functional Partners:

LOC100856560

0.899

ENSCAFP00000044371

0.890

ESR1

0.733

TRIM33

0.716

TP53

0.638

SETDB1

0.611

SMARCAD1

0.606

NR3C2

0.585

SIRT1

0.574

KDM1A

0.574

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSCAFP00000044371	ESR1	ENSCAFP00000044371	ENSCAFP00000000624	Uncharacterized protein.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.733
ENSCAFP00000044371	KDM1A	ENSCAFP00000044371	ENSCAFP00000053375	Uncharacterized protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.574
ENSCAFP00000044371	LOC100856461	ENSCAFP00000044371	ENSCAFP00000006448	Uncharacterized protein.	Bromo domain-containing protein.	0.890
ENSCAFP00000044371	NR3C2	ENSCAFP00000044371	ENSCAFP00000054841	Uncharacterized protein.	Nuclear receptor subfamily 3 group C member 2.	0.585
ENSCAFP00000044371	SETDB1	ENSCAFP00000044371	ENSCAFP00000041684	Uncharacterized protein.	SET domain bifurcated histone lysine methyltransferase 1.	0.611
ENSCAFP00000044371	SIRT1	ENSCAFP00000044371	ENSCAFP00000019617	Uncharacterized protein.	Sirtuin 1.	0.481
ENSCAFP00000044371	SMARCAD1	ENSCAFP00000044371	ENSCAFP00000042662	Uncharacterized protein.	Uncharacterized protein.	0.606
ENSCAFP00000044371	TP53	ENSCAFP00000044371	ENSCAFP00000064590	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.638
ENSCAFP00000044371	TRIM33	ENSCAFP00000044371	ENSCAFP00000013912	Uncharacterized protein.	Tripartite motif containing 33.	0.716
ESR1	ENSCAFP00000044371	ENSCAFP00000000624	ENSCAFP00000044371	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Uncharacterized protein.	0.733
ESR1	KDM1A	ENSCAFP00000000624	ENSCAFP00000053375	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.739
ESR1	LOC100856461	ENSCAFP00000000624	ENSCAFP00000006448	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Bromo domain-containing protein.	0.733
ESR1	LOC100856560	ENSCAFP00000000624	ENSCAFP00000048889	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	RING-type domain-containing protein.	0.733
ESR1	NR3C2	ENSCAFP00000000624	ENSCAFP00000054841	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor subfamily 3 group C member 2.	0.590
ESR1	SIRT1	ENSCAFP00000000624	ENSCAFP00000019617	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sirtuin 1.	0.562
ESR1	TP53	ENSCAFP00000000624	ENSCAFP00000064590	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.973
ESR1	TRIM33	ENSCAFP00000000624	ENSCAFP00000013912	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tripartite motif containing 33.	0.425
KDM1A	ENSCAFP00000044371	ENSCAFP00000053375	ENSCAFP00000044371	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Uncharacterized protein.	0.574
KDM1A	ESR1	ENSCAFP00000053375	ENSCAFP00000000624	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.739
KDM1A	LOC100856461	ENSCAFP00000053375	ENSCAFP00000006448	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	Bromo domain-containing protein.	0.574