MAGI2 protein (Canis lupus familiaris) - STRING interaction network

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MAGI2

Membrane associated guanylate kinase, WW and PDZ domain containing 2. (1169 aa)

Predicted Functional Partners:

PTEN

0.957

CTNNB1

0.956

RAPGEF2

0.935

RAPGEF6

0.924

LOC606856

0.914

MAGI3

0.894

MAGI1

0.881

IGSF5

0.840

DLGAP1

0.836

ARHGEF16

0.777

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF16	MAGI2	ENSCAFP00000039810	ENSCAFP00000006489	Rho guanine nucleotide exchange factor 16.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.777
CTNNB1	LOC606856	ENSCAFP00000007783	ENSCAFP00000008915	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Uncharacterized protein.	0.496
CTNNB1	MAGI1	ENSCAFP00000007783	ENSCAFP00000058124	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Membrane associated guanylate kinase, WW and PDZ domain containing 1.	0.973
CTNNB1	MAGI2	ENSCAFP00000007783	ENSCAFP00000006489	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.956
CTNNB1	MAGI3	ENSCAFP00000007783	ENSCAFP00000019378	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	0.956
CTNNB1	PTEN	ENSCAFP00000007783	ENSCAFP00000045099	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...]	0.810
CTNNB1	RAPGEF2	ENSCAFP00000007783	ENSCAFP00000066461	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...]	0.592
DLGAP1	MAGI1	ENSCAFP00000046340	ENSCAFP00000058124	DLG associated protein 1.	Membrane associated guanylate kinase, WW and PDZ domain containing 1.	0.544
DLGAP1	MAGI2	ENSCAFP00000046340	ENSCAFP00000006489	DLG associated protein 1.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.836
DLGAP1	MAGI3	ENSCAFP00000046340	ENSCAFP00000019378	DLG associated protein 1.	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	0.417
IGSF5	MAGI1	ENSCAFP00000014803	ENSCAFP00000058124	Immunoglobulin superfamily member 5.	Membrane associated guanylate kinase, WW and PDZ domain containing 1.	0.953
IGSF5	MAGI2	ENSCAFP00000014803	ENSCAFP00000006489	Immunoglobulin superfamily member 5.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.840
IGSF5	MAGI3	ENSCAFP00000014803	ENSCAFP00000019378	Immunoglobulin superfamily member 5.	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	0.783
LOC606856	CTNNB1	ENSCAFP00000008915	ENSCAFP00000007783	Uncharacterized protein.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.496
LOC606856	MAGI1	ENSCAFP00000008915	ENSCAFP00000058124	Uncharacterized protein.	Membrane associated guanylate kinase, WW and PDZ domain containing 1.	0.863
LOC606856	MAGI2	ENSCAFP00000008915	ENSCAFP00000006489	Uncharacterized protein.	Membrane associated guanylate kinase, WW and PDZ domain containing 2.	0.914
LOC606856	MAGI3	ENSCAFP00000008915	ENSCAFP00000019378	Uncharacterized protein.	Membrane associated guanylate kinase, WW and PDZ domain containing 3.	0.478
MAGI1	CTNNB1	ENSCAFP00000058124	ENSCAFP00000007783	Membrane associated guanylate kinase, WW and PDZ domain containing 1.	Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...]	0.973
MAGI1	DLGAP1	ENSCAFP00000058124	ENSCAFP00000046340	Membrane associated guanylate kinase, WW and PDZ domain containing 1.	DLG associated protein 1.	0.544
MAGI1	IGSF5	ENSCAFP00000058124	ENSCAFP00000014803	Membrane associated guanylate kinase, WW and PDZ domain containing 1.	Immunoglobulin superfamily member 5.	0.953