STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
E2RDS0_CANLFTYR_PHOSPHATASE_2 domain-containing protein. (173 aa)    
Predicted Functional Partners:
SPINK2
Serine peptidase inhibitor, Kazal type 2.
   
    0.805
CNNM3
Cyclin and CBS domain divalent metal cation transport mediator 4.
    
 
 0.588
FUCA1
Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.
      
 0.559
CHFR
Checkpoint with forkhead and ring finger domains.
      
 0.554
ARL15
ADP ribosylation factor like GTPase 15.
   
 
 0.543
MBLAC2
Metallo-beta-lactamase domain containing 2.
    
 
 0.483
TAF12
TFIID_20kDa domain-containing protein.
      
 0.480
J9NXV6_CANLF
TFIID_20kDa domain-containing protein.
      
 0.480
ENSCAFP00000040836
annotation not available
      
 0.480
PMAIP1
Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 and with BIM/BCL2L11 for binding to MCL1; can displace BAK1 and BIM/BCL2L11 from their binding sites (By similarity). Belongs to the PMAIP1 family.
      
 0.477
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.