STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (314 aa)    
Predicted Functional Partners:
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit.
   
 0.996
XPA
XPA, DNA damage recognition and repair factor.
    
 0.995
FANCM
FA complementation group M.
   
 0.988
MUS81
MUS81 structure-specific endonuclease subunit.
   
 0.985
SLX4
SLX4 structure-specific endonuclease subunit.
   
 0.962
SLX1A
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.
   
 0.935
FANCD2
FA complementation group D2.
    
 0.917
FANCL
FA complementation group L.
    
 0.909
FANCG
FA complementation group G.
    
 0.907
EME1
Essential meiotic structure-specific endonuclease 1.
    
 0.907
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.