ERCC3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

ERCC3

ERCC excision repair 3, TFIIH core complex helicase subunit. (779 aa)

Predicted Functional Partners:

ERCC2

0.993

GTF2H5

0.982

GTF2H1

0.975

GTF2H4

0.974

CCNH

0.966

CDK7

0.963

GTF2H3

0.960

XPA

0.957

MNAT1

0.957

ERCC4

0.955

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNH	CDK7	ENSCAFP00000031379	ENSCAFP00000011477	Cyclin H; Belongs to the cyclin family.	Cyclin dependent kinase 7.	0.999
CCNH	ERCC2	ENSCAFP00000031379	ENSCAFP00000062336	Cyclin H; Belongs to the cyclin family.	ERCC excision repair 2, TFIIH core complex helicase subunit.	0.967
CCNH	ERCC3	ENSCAFP00000031379	ENSCAFP00000006738	Cyclin H; Belongs to the cyclin family.	ERCC excision repair 3, TFIIH core complex helicase subunit.	0.966
CCNH	ERCC4	ENSCAFP00000031379	ENSCAFP00000027778	Cyclin H; Belongs to the cyclin family.	ERCC excision repair 4, endonuclease catalytic subunit.	0.602
CCNH	GTF2H1	ENSCAFP00000031379	ENSCAFP00000013505	Cyclin H; Belongs to the cyclin family.	General transcription factor IIH subunit 1.	0.982
CCNH	GTF2H3	ENSCAFP00000031379	ENSCAFP00000064318	Cyclin H; Belongs to the cyclin family.	General transcription factor IIH subunit 3.	0.945
CCNH	GTF2H4	ENSCAFP00000031379	ENSCAFP00000000671	Cyclin H; Belongs to the cyclin family.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.980
CCNH	GTF2H5	ENSCAFP00000031379	ENSCAFP00000036445	Cyclin H; Belongs to the cyclin family.	General transcription factor IIH subunit 5.	0.924
CCNH	MNAT1	ENSCAFP00000031379	ENSCAFP00000058747	Cyclin H; Belongs to the cyclin family.	MNAT1 component of CDK activating kinase.	0.997
CCNH	XPA	ENSCAFP00000031379	ENSCAFP00000003578	Cyclin H; Belongs to the cyclin family.	XPA, DNA damage recognition and repair factor.	0.715
CDK7	CCNH	ENSCAFP00000011477	ENSCAFP00000031379	Cyclin dependent kinase 7.	Cyclin H; Belongs to the cyclin family.	0.999
CDK7	ERCC2	ENSCAFP00000011477	ENSCAFP00000062336	Cyclin dependent kinase 7.	ERCC excision repair 2, TFIIH core complex helicase subunit.	0.966
CDK7	ERCC3	ENSCAFP00000011477	ENSCAFP00000006738	Cyclin dependent kinase 7.	ERCC excision repair 3, TFIIH core complex helicase subunit.	0.963
CDK7	ERCC4	ENSCAFP00000011477	ENSCAFP00000027778	Cyclin dependent kinase 7.	ERCC excision repair 4, endonuclease catalytic subunit.	0.557
CDK7	GTF2H1	ENSCAFP00000011477	ENSCAFP00000013505	Cyclin dependent kinase 7.	General transcription factor IIH subunit 1.	0.977
CDK7	GTF2H3	ENSCAFP00000011477	ENSCAFP00000064318	Cyclin dependent kinase 7.	General transcription factor IIH subunit 3.	0.973
CDK7	GTF2H4	ENSCAFP00000011477	ENSCAFP00000000671	Cyclin dependent kinase 7.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.963
CDK7	GTF2H5	ENSCAFP00000011477	ENSCAFP00000036445	Cyclin dependent kinase 7.	General transcription factor IIH subunit 5.	0.948
CDK7	MNAT1	ENSCAFP00000011477	ENSCAFP00000058747	Cyclin dependent kinase 7.	MNAT1 component of CDK activating kinase.	0.979
CDK7	XPA	ENSCAFP00000011477	ENSCAFP00000003578	Cyclin dependent kinase 7.	XPA, DNA damage recognition and repair factor.	0.678