Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
TTYH2Protein tweety homolog; Probable chloride channel; Belongs to the tweety family. (497 aa)    
Predicted Functional Partners:
LRRC8E
Leucine rich repeat containing 8 VRAC subunit E.
      
 0.682
LRRC8C
Leucine rich repeat containing 8 VRAC subunit C.
      
 0.660
C1GALT1
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.
      
 0.598
EVC2
EvC ciliary complex subunit 2.
     
 0.593
EVC
EvC ciliary complex subunit 1.
     
  0.593
EFCAB7
EF-hand calcium binding domain 7.
     
  0.593
APOE
Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...]
    
   0.567
KCP
Kielin cysteine rich BMP regulator.
      
 0.562
TMEM243
Transmembrane protein 243.
      
 0.526
LRRC8A
Leucine rich repeat containing 8 VRAC subunit A.
      
 0.524
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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