STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RELBRELB proto-oncogene, NF-kB subunit. (560 aa)    
Predicted Functional Partners:
NFKB2
Nuclear factor kappa B subunit 2.
   
0.999
RELA
RELA proto-oncogene, NF-kB subunit.
  
0.998
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
   
 0.977
NFKB1
Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]
   
0.977
REL
REL proto-oncogene, NF-kB subunit.
   
 
0.943
NFKBIE
ANK_REP_REGION domain-containing protein.
   
 
 0.867
NFKBIA
NFKB inhibitor alpha.
 
 
 
 0.846
MAP3K14
Mitogen-activated protein kinase kinase kinase 14.
   
 0.810
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
   
 
 0.799
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
   
 
 0.790
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.