STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBLCCbl proto-oncogene C. (497 aa)    
Predicted Functional Partners:
EGFR
Receptor protein-tyrosine kinase.
   
 0.970
MST1R
Macrophage stimulating 1 receptor.
   
 
 0.917
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
   
 
 0.915
CBLB
Cbl proto-oncogene B.
  
 
 
0.909
CBL
Cbl proto-oncogene.
  
 
 
0.908
SH3KBP1
SH3 domain containing kinase binding protein 1.
    
 0.902
SH3GL2
SH3 domain containing GRB2 like 2, endophilin A1.
    
 0.812
SH3GL3
SH3 domain containing GRB2 like 3, endophilin A3.
   
 0.812
SH3GL1
SH3 domain containing GRB2 like 1, endophilin A2.
    
 0.812
SH3GLB2
SH3 domain containing GRB2 like, endophilin B2.
   
 
  0.800
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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