Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
BCL3BCL3 transcription coactivator. (566 aa)    
Predicted Functional Partners:
NFKB1
Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]
   
 0.979
CYLD
CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.
   
 0.965
NFKB2
Nuclear factor kappa B subunit 2.
  
0.949
RELB
RELB proto-oncogene, NF-kB subunit.
   
 0.697
REL
REL proto-oncogene, NF-kB subunit.
   
 0.667
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
   
 0.657
RELA
RELA proto-oncogene, NF-kB subunit.
   
 0.604
CPS1
Carbamoyl-phosphate synthase 1.
    
 0.598
NAGS
N-acetylglutamate synthase.
   
  
 0.593
STRC
Stereocilin.
    
 0.591
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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