STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ZNF227Zinc finger protein 227. (812 aa)    
Predicted Functional Partners:
UBE2V2
Ubiquitin conjugating enzyme E2 V2.
      
 0.875
TMEM47
Transmembrane protein 47; Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity); Belongs to the TMEM47 family.
   
  
 0.807
RIMBP2
RIMS binding protein 2.
   
  
 0.718
CYP4A11
Uncharacterized protein; Belongs to the cytochrome P450 family.
   
 
 0.582
ANKMY1
Ankyrin repeat and MYND domain containing 1.
    
 
 0.544
LRRIQ1
Leucine rich repeats and IQ motif containing 1.
    
 
 0.532
PRPF40A
Pre-mRNA processing factor 40 homolog A.
    
 
 0.470
LUC7L
LUC7 like.
   
  
 0.450
SPRY3
Sprouty RTK signaling antagonist 3.
      
 0.440
MTERF3
Mitochondrial transcription termination factor 3.
      
 0.435
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.