Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PLAURPlasminogen activator, urokinase receptor. (374 aa)    
Predicted Functional Partners:
PLAU
Plasminogen activator, urokinase.
   
 0.998
J9NXN6_CANLF
Uncharacterized protein; Belongs to the peptidase S1 family.
   
 0.905
PLAT
Uncharacterized protein.
   
 0.905
VTN
SMB domain-containing protein.
    
 
 0.864
SERPINE1
Serpin family E member 1; Belongs to the serpin family.
   
 
 0.733
PLG
Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...]
    
 0.700
PINLYP
Phospholipase A2 inhibitor and LY6/PLAUR domain containing.
      
 0.691
CD55
CD55 molecule.
   
  
 0.613
SELENBP1
Selenium binding protein 1.
    
 
 0.600
TIMP1
Metalloproteinase inhibitor 1.
   
  
 0.590
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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