STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OPTNOptineurin. (608 aa)    
Predicted Functional Partners:
TBK1
TANK binding kinase 1.
   
 0.944
GABARAPL1
GABA type A receptor associated protein like 1.
   
 0.925
GABARAPL2
GABA type A receptor associated protein like 2.
   
 0.912
TANK
TRAF family member associated NFKB activator.
   
 
 0.905
CHUK
Component of inhibitor of nuclear factor kappa B kinase complex.
    
 0.806
IKBKB
Inhibitor of nuclear factor kappa B kinase subunit beta.
    
 0.806
RAB8B
RAB8B, member RAS oncogene family.
   
 
 0.782
RAB8A
Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...]
   
 
 0.776
PLK1
Serine/threonine-protein kinase PLK.
     
  0.750
OFD1
OFD1 centriole and centriolar satellite protein.
  
 0.687
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.