MLH1 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

MLH1

MutL homolog 1. (757 aa)

Predicted Functional Partners:

MSH2

0.999

MSH6

0.999

PMS1

0.998

PMS2

0.998

FAN1

0.993

MSH3

0.990

EXO1

0.985

BRCA1

0.981

BLM

0.962

PCNA

0.959

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	BRCA1	ENSCAFP00000018251	ENSCAFP00000048759	BLM RecQ like helicase.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.921
BLM	EXO1	ENSCAFP00000018251	ENSCAFP00000023179	BLM RecQ like helicase.	Exonuclease 1.	0.986
BLM	FAN1	ENSCAFP00000018251	ENSCAFP00000015212	BLM RecQ like helicase.	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.	0.548
BLM	MLH1	ENSCAFP00000018251	ENSCAFP00000007136	BLM RecQ like helicase.	MutL homolog 1.	0.962
BLM	MSH2	ENSCAFP00000018251	ENSCAFP00000003876	BLM RecQ like helicase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.878
BLM	MSH3	ENSCAFP00000018251	ENSCAFP00000012938	BLM RecQ like helicase.	MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR).	0.562
BLM	MSH6	ENSCAFP00000018251	ENSCAFP00000040899	BLM RecQ like helicase.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.896
BLM	PCNA	ENSCAFP00000018251	ENSCAFP00000009045	BLM RecQ like helicase.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.874
BLM	PMS1	ENSCAFP00000018251	ENSCAFP00000060101	BLM RecQ like helicase.	PMS1 homolog 1, mismatch repair system component.	0.441
BLM	PMS2	ENSCAFP00000018251	ENSCAFP00000061828	BLM RecQ like helicase.	PMS1 homolog 2, mismatch repair system component.	0.509
BRCA1	BLM	ENSCAFP00000048759	ENSCAFP00000018251	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BLM RecQ like helicase.	0.921
BRCA1	EXO1	ENSCAFP00000048759	ENSCAFP00000023179	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Exonuclease 1.	0.874
BRCA1	MLH1	ENSCAFP00000048759	ENSCAFP00000007136	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutL homolog 1.	0.981
BRCA1	MSH2	ENSCAFP00000048759	ENSCAFP00000003876	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.955
BRCA1	MSH3	ENSCAFP00000048759	ENSCAFP00000012938	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	MutS homolog 3; Component of the post-replicative DNA mismatch repair system (MMR).	0.612
BRCA1	MSH6	ENSCAFP00000048759	ENSCAFP00000040899	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.927
BRCA1	PCNA	ENSCAFP00000048759	ENSCAFP00000009045	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.719
BRCA1	PMS2	ENSCAFP00000048759	ENSCAFP00000061828	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	PMS1 homolog 2, mismatch repair system component.	0.709
EXO1	BLM	ENSCAFP00000023179	ENSCAFP00000018251	Exonuclease 1.	BLM RecQ like helicase.	0.986
EXO1	BRCA1	ENSCAFP00000023179	ENSCAFP00000048759	Exonuclease 1.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.874