STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DEDD2Death effector domain containing 2. (329 aa)    
Predicted Functional Partners:
CFLAR
CASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family.
    
 
 0.603
CASP8
Caspase 8; Belongs to the peptidase C14A family.
    
 
 0.573
DEDD
Death effector domain containing.
    
   0.573
ATG16L1
Autophagy related 16 like 1.
    
   0.573
MACO1
Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family.
      
 0.568
LCMT1
Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.
      
 0.474
C34H3orf70
Chromosome 34 C3orf70 homolog.
      
 0.472
CCDC73
Coiled-coil domain containing 73.
      
 0.472
INSIG1
Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.
      
 0.462
FBXO38
F-box protein 38.
    
 
 0.443
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.