node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARPC2 | SNX11 | ENSCAFP00000021552 | ENSCAFP00000051790 | Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. | Sorting nexin 11. | 0.514 |
ARPC2 | UNC13D | ENSCAFP00000021552 | ENSCAFP00000007361 | Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. | Unc-13 homolog D. | 0.485 |
FHL2 | STX11 | ENSCAFP00000003094 | ENSCAFP00000051697 | Four and a half LIM domains 2. | Syntaxin 11; Belongs to the syntaxin family. | 0.682 |
FHL2 | STX19 | ENSCAFP00000003094 | ENSCAFP00000013264 | Four and a half LIM domains 2. | Syntaxin 19; Belongs to the syntaxin family. | 0.482 |
FHL2 | STXBP2 | ENSCAFP00000003094 | ENSCAFP00000027039 | Four and a half LIM domains 2. | Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family. | 0.685 |
FHL2 | UNC13D | ENSCAFP00000003094 | ENSCAFP00000007361 | Four and a half LIM domains 2. | Unc-13 homolog D. | 0.544 |
LYST | RAB27A | ENSCAFP00000063660 | ENSCAFP00000023411 | Lysosomal trafficking regulator. | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | 0.618 |
LYST | SH2D1A | ENSCAFP00000063660 | ENSCAFP00000041409 | Lysosomal trafficking regulator. | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. | 0.696 |
LYST | STX11 | ENSCAFP00000063660 | ENSCAFP00000051697 | Lysosomal trafficking regulator. | Syntaxin 11; Belongs to the syntaxin family. | 0.590 |
LYST | STX19 | ENSCAFP00000063660 | ENSCAFP00000013264 | Lysosomal trafficking regulator. | Syntaxin 19; Belongs to the syntaxin family. | 0.482 |
LYST | STXBP2 | ENSCAFP00000063660 | ENSCAFP00000027039 | Lysosomal trafficking regulator. | Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family. | 0.451 |
LYST | UNC13D | ENSCAFP00000063660 | ENSCAFP00000007361 | Lysosomal trafficking regulator. | Unc-13 homolog D. | 0.652 |
PRF1 | STX11 | ENSCAFP00000020751 | ENSCAFP00000051697 | Perforin 1. | Syntaxin 11; Belongs to the syntaxin family. | 0.591 |
PRF1 | STX19 | ENSCAFP00000020751 | ENSCAFP00000013264 | Perforin 1. | Syntaxin 19; Belongs to the syntaxin family. | 0.564 |
PRF1 | UNC13D | ENSCAFP00000020751 | ENSCAFP00000007361 | Perforin 1. | Unc-13 homolog D. | 0.647 |
RAB27A | LYST | ENSCAFP00000023411 | ENSCAFP00000063660 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Lysosomal trafficking regulator. | 0.618 |
RAB27A | SH2D1A | ENSCAFP00000023411 | ENSCAFP00000041409 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. | 0.507 |
RAB27A | STX11 | ENSCAFP00000023411 | ENSCAFP00000051697 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Syntaxin 11; Belongs to the syntaxin family. | 0.583 |
RAB27A | STX19 | ENSCAFP00000023411 | ENSCAFP00000013264 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Syntaxin 19; Belongs to the syntaxin family. | 0.483 |
RAB27A | STXBP2 | ENSCAFP00000023411 | ENSCAFP00000027039 | Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. | Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family. | 0.411 |