UNC13D protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

UNC13D

Unc-13 homolog D. (1210 aa)

Predicted Functional Partners:

STX11

0.886

STXBP2

0.867

RAB27A

0.764

RAB27B

0.725

PRF1

0.715

LYST

0.696

STX19

0.680

SH2D1A

0.635

FHL2

0.608

ZXDC

0.517

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FHL2	STX11	ENSCAFP00000003094	ENSCAFP00000051697	Four and a half LIM domains 2.	Syntaxin 11; Belongs to the syntaxin family.	0.701
FHL2	STXBP2	ENSCAFP00000003094	ENSCAFP00000027039	Four and a half LIM domains 2.	Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family.	0.722
FHL2	UNC13D	ENSCAFP00000003094	ENSCAFP00000007361	Four and a half LIM domains 2.	Unc-13 homolog D.	0.608
LYST	RAB27A	ENSCAFP00000063660	ENSCAFP00000023411	Lysosomal trafficking regulator.	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	0.612
LYST	SH2D1A	ENSCAFP00000063660	ENSCAFP00000041409	Lysosomal trafficking regulator.	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.	0.659
LYST	STX11	ENSCAFP00000063660	ENSCAFP00000051697	Lysosomal trafficking regulator.	Syntaxin 11; Belongs to the syntaxin family.	0.582
LYST	STXBP2	ENSCAFP00000063660	ENSCAFP00000027039	Lysosomal trafficking regulator.	Syntaxin-binding protein 2; Involved in the protein trafficking from the Golgi apparatus to the plasma membrane; Belongs to the STXBP/unc-18/SEC1 family.	0.574
LYST	UNC13D	ENSCAFP00000063660	ENSCAFP00000007361	Lysosomal trafficking regulator.	Unc-13 homolog D.	0.696
PRF1	SH2D1A	ENSCAFP00000020751	ENSCAFP00000041409	Perforin 1.	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.	0.468
PRF1	STX11	ENSCAFP00000020751	ENSCAFP00000051697	Perforin 1.	Syntaxin 11; Belongs to the syntaxin family.	0.593
PRF1	STX19	ENSCAFP00000020751	ENSCAFP00000013264	Perforin 1.	Syntaxin 19; Belongs to the syntaxin family.	0.518
PRF1	UNC13D	ENSCAFP00000020751	ENSCAFP00000007361	Perforin 1.	Unc-13 homolog D.	0.715
RAB27A	LYST	ENSCAFP00000023411	ENSCAFP00000063660	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Lysosomal trafficking regulator.	0.612
RAB27A	SH2D1A	ENSCAFP00000023411	ENSCAFP00000041409	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.	0.464
RAB27A	STX11	ENSCAFP00000023411	ENSCAFP00000051697	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Syntaxin 11; Belongs to the syntaxin family.	0.629
RAB27A	STX19	ENSCAFP00000023411	ENSCAFP00000013264	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Syntaxin 19; Belongs to the syntaxin family.	0.550
RAB27A	UNC13D	ENSCAFP00000023411	ENSCAFP00000007361	Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.	Unc-13 homolog D.	0.764
RAB27B	UNC13D	ENSCAFP00000000213	ENSCAFP00000007361	RAB27B, member RAS oncogene family.	Unc-13 homolog D.	0.725
SH2D1A	LYST	ENSCAFP00000041409	ENSCAFP00000063660	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.	Lysosomal trafficking regulator.	0.659
SH2D1A	PRF1	ENSCAFP00000041409	ENSCAFP00000020751	SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.	Perforin 1.	0.468