node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IRAK1 | IRAK4 | ENSCAFP00000047467 | ENSCAFP00000014260 | Interleukin 1 receptor associated kinase 1. | Interleukin 1 receptor associated kinase 4. | 0.996 |
IRAK1 | MAP3K7 | ENSCAFP00000047467 | ENSCAFP00000004664 | Interleukin 1 receptor associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.794 |
IRAK1 | MYD88 | ENSCAFP00000047467 | ENSCAFP00000007386 | Interleukin 1 receptor associated kinase 1. | MYD88 innate immune signal transduction adaptor. | 0.999 |
IRAK1 | TIRAP | ENSCAFP00000047467 | ENSCAFP00000030551 | Interleukin 1 receptor associated kinase 1. | TIR domain containing adaptor protein. | 0.709 |
IRAK1 | TLR1 | ENSCAFP00000047467 | ENSCAFP00000032660 | Interleukin 1 receptor associated kinase 1. | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.639 |
IRAK1 | TLR2 | ENSCAFP00000047467 | ENSCAFP00000012269 | Interleukin 1 receptor associated kinase 1. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.704 |
IRAK1 | TLR5 | ENSCAFP00000047467 | ENSCAFP00000016726 | Interleukin 1 receptor associated kinase 1. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.588 |
IRAK1 | TLR6 | ENSCAFP00000047467 | ENSCAFP00000023836 | Interleukin 1 receptor associated kinase 1. | Toll like receptor 6; Belongs to the Toll-like receptor family. | 0.778 |
IRAK1 | TLR7 | ENSCAFP00000047467 | ENSCAFP00000043898 | Interleukin 1 receptor associated kinase 1. | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.647 |
IRAK1 | TRAF6 | ENSCAFP00000047467 | ENSCAFP00000010159 | Interleukin 1 receptor associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |
IRAK4 | IRAK1 | ENSCAFP00000014260 | ENSCAFP00000047467 | Interleukin 1 receptor associated kinase 4. | Interleukin 1 receptor associated kinase 1. | 0.996 |
IRAK4 | MAP3K7 | ENSCAFP00000014260 | ENSCAFP00000004664 | Interleukin 1 receptor associated kinase 4. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.924 |
IRAK4 | MYD88 | ENSCAFP00000014260 | ENSCAFP00000007386 | Interleukin 1 receptor associated kinase 4. | MYD88 innate immune signal transduction adaptor. | 0.999 |
IRAK4 | TIRAP | ENSCAFP00000014260 | ENSCAFP00000030551 | Interleukin 1 receptor associated kinase 4. | TIR domain containing adaptor protein. | 0.981 |
IRAK4 | TLR1 | ENSCAFP00000014260 | ENSCAFP00000032660 | Interleukin 1 receptor associated kinase 4. | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.525 |
IRAK4 | TLR2 | ENSCAFP00000014260 | ENSCAFP00000012269 | Interleukin 1 receptor associated kinase 4. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.710 |
IRAK4 | TLR5 | ENSCAFP00000014260 | ENSCAFP00000016726 | Interleukin 1 receptor associated kinase 4. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.538 |
IRAK4 | TLR6 | ENSCAFP00000014260 | ENSCAFP00000023836 | Interleukin 1 receptor associated kinase 4. | Toll like receptor 6; Belongs to the Toll-like receptor family. | 0.633 |
IRAK4 | TLR7 | ENSCAFP00000014260 | ENSCAFP00000043898 | Interleukin 1 receptor associated kinase 4. | Toll like receptor 7; Belongs to the Toll-like receptor family. | 0.650 |
IRAK4 | TRAF6 | ENSCAFP00000014260 | ENSCAFP00000010159 | Interleukin 1 receptor associated kinase 4. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.999 |