PAK3 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

PAK3

P21 (RAC1) activated kinase 3. (583 aa)

Predicted Functional Partners:

ARHGEF6

0.989

NCK1

0.980

NCK2

0.979

CDC42-2

0.977

PAK2

0.977

RAC1

0.965

ARHGEF7

0.962

LIMK1

0.958

RAF1

0.948

RAC2

0.941

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF6	ARHGEF7	ENSCAFP00000057862	ENSCAFP00000061674	Rac/Cdc42 guanine nucleotide exchange factor 6.	Rho guanine nucleotide exchange factor 7.	0.881
ARHGEF6	CDC42-2	ENSCAFP00000057862	ENSCAFP00000060180	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.873
ARHGEF6	NCK1	ENSCAFP00000057862	ENSCAFP00000011072	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cytoplasmic protein.	0.738
ARHGEF6	NCK2	ENSCAFP00000057862	ENSCAFP00000003087	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cytoplasmic protein.	0.819
ARHGEF6	PAK2	ENSCAFP00000057862	ENSCAFP00000064510	Rac/Cdc42 guanine nucleotide exchange factor 6.	Non-specific serine/threonine protein kinase.	0.984
ARHGEF6	PAK3	ENSCAFP00000057862	ENSCAFP00000007390	Rac/Cdc42 guanine nucleotide exchange factor 6.	P21 (RAC1) activated kinase 3.	0.989
ARHGEF6	RAC1	ENSCAFP00000057862	ENSCAFP00000032062	Rac/Cdc42 guanine nucleotide exchange factor 6.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.935
ARHGEF6	RAC2	ENSCAFP00000057862	ENSCAFP00000002174	Rac/Cdc42 guanine nucleotide exchange factor 6.	Rac family small GTPase 2.	0.942
ARHGEF7	ARHGEF6	ENSCAFP00000061674	ENSCAFP00000057862	Rho guanine nucleotide exchange factor 7.	Rac/Cdc42 guanine nucleotide exchange factor 6.	0.881
ARHGEF7	CDC42-2	ENSCAFP00000061674	ENSCAFP00000060180	Rho guanine nucleotide exchange factor 7.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.814
ARHGEF7	NCK1	ENSCAFP00000061674	ENSCAFP00000011072	Rho guanine nucleotide exchange factor 7.	Cytoplasmic protein.	0.582
ARHGEF7	NCK2	ENSCAFP00000061674	ENSCAFP00000003087	Rho guanine nucleotide exchange factor 7.	Cytoplasmic protein.	0.711
ARHGEF7	PAK2	ENSCAFP00000061674	ENSCAFP00000064510	Rho guanine nucleotide exchange factor 7.	Non-specific serine/threonine protein kinase.	0.975
ARHGEF7	PAK3	ENSCAFP00000061674	ENSCAFP00000007390	Rho guanine nucleotide exchange factor 7.	P21 (RAC1) activated kinase 3.	0.962
ARHGEF7	RAC1	ENSCAFP00000061674	ENSCAFP00000032062	Rho guanine nucleotide exchange factor 7.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.893
ARHGEF7	RAC2	ENSCAFP00000061674	ENSCAFP00000002174	Rho guanine nucleotide exchange factor 7.	Rac family small GTPase 2.	0.942
CDC42-2	ARHGEF6	ENSCAFP00000060180	ENSCAFP00000057862	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rac/Cdc42 guanine nucleotide exchange factor 6.	0.873
CDC42-2	ARHGEF7	ENSCAFP00000060180	ENSCAFP00000061674	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rho guanine nucleotide exchange factor 7.	0.814
CDC42-2	LIMK1	ENSCAFP00000060180	ENSCAFP00000018366	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	LIM domain kinase 1.	0.724
CDC42-2	NCK1	ENSCAFP00000060180	ENSCAFP00000011072	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Cytoplasmic protein.	0.737