STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TIMP4Metalloproteinase inhibitor 4. (224 aa)    
Predicted Functional Partners:
MMP9
Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity).
    
 
 0.832
MMP8
Matrix metallopeptidase 8.
    
 
 0.772
MMP3
Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase (By similarity); Belongs to the peptidase M10A family.
    
 
 0.673
MMP14
Matrix metallopeptidase 14.
    
 
 0.660
MMP2
Matrix metallopeptidase 2.
    
 
 0.656
MMP7
Matrix metallopeptidase 7.
    
 
 0.650
MMP13
Matrix metallopeptidase 13.
    
 
 0.619
MMP16
Matrix metallopeptidase 16.
    
 
 0.603
MMP1
Matrix metallopeptidase 1.
    
 
 0.603
MMP28
Matrix metallopeptidase 28.
    
 
 0.573
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.