GATA3 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

GATA3

GATA binding protein 3. (444 aa)

Predicted Functional Partners:

TBX21

0.989

FOXP3

0.930

IL4

0.929

IL5

0.912

LMCD1

0.904

IL13

0.869

IFNG

0.866

ESR1

0.855

STAT6

0.851

GATA2

0.819

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	GATA2	ENSCAFP00000000624	ENSCAFP00000006152	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	GATA binding protein 2.	0.577
ESR1	GATA3	ENSCAFP00000000624	ENSCAFP00000007467	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	GATA binding protein 3.	0.855
ESR1	IFNG	ENSCAFP00000000624	ENSCAFP00000000588	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.425
ESR1	STAT6	ENSCAFP00000000624	ENSCAFP00000046565	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Signal transducer and activator of transcription.	0.550
FOXP3	GATA2	ENSCAFP00000023435	ENSCAFP00000006152	Forkhead box P3.	GATA binding protein 2.	0.460
FOXP3	GATA3	ENSCAFP00000023435	ENSCAFP00000007467	Forkhead box P3.	GATA binding protein 3.	0.930
FOXP3	IFNG	ENSCAFP00000023435	ENSCAFP00000000588	Forkhead box P3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.934
FOXP3	IL13	ENSCAFP00000023435	ENSCAFP00000001250	Forkhead box P3.	Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.	0.797
FOXP3	IL4	ENSCAFP00000023435	ENSCAFP00000001253	Forkhead box P3.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.891
FOXP3	IL5	ENSCAFP00000023435	ENSCAFP00000001224	Forkhead box P3.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.766
FOXP3	STAT6	ENSCAFP00000023435	ENSCAFP00000046565	Forkhead box P3.	Signal transducer and activator of transcription.	0.699
FOXP3	TBX21	ENSCAFP00000023435	ENSCAFP00000024565	Forkhead box P3.	T-box transcription factor 21.	0.758
GATA2	ESR1	ENSCAFP00000006152	ENSCAFP00000000624	GATA binding protein 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.577
GATA2	FOXP3	ENSCAFP00000006152	ENSCAFP00000023435	GATA binding protein 2.	Forkhead box P3.	0.460
GATA2	GATA3	ENSCAFP00000006152	ENSCAFP00000007467	GATA binding protein 2.	GATA binding protein 3.	0.819
GATA2	IL5	ENSCAFP00000006152	ENSCAFP00000001224	GATA binding protein 2.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.442
GATA2	TBX21	ENSCAFP00000006152	ENSCAFP00000024565	GATA binding protein 2.	T-box transcription factor 21.	0.865
GATA3	ESR1	ENSCAFP00000007467	ENSCAFP00000000624	GATA binding protein 3.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.855
GATA3	FOXP3	ENSCAFP00000007467	ENSCAFP00000023435	GATA binding protein 3.	Forkhead box P3.	0.930
GATA3	GATA2	ENSCAFP00000007467	ENSCAFP00000006152	GATA binding protein 3.	GATA binding protein 2.	0.819