STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYP2A13Uncharacterized protein; Belongs to the cytochrome P450 family. (528 aa)    
Predicted Functional Partners:
CYP1A2
Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...]
  
 
0.934
LOC610164
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.922
HSD11B1L
Hydroxysteroid 11-beta dehydrogenase 1 like.
   
 0.922
CBR3
Carbonyl reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.921
UGT1A6
UDPGT domain-containing protein; Belongs to the UDP-glycosyltransferase family.
   
 0.919
LOC480777
UDP-glucuronosyltransferase 2B31; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity on phenols, opioids, and carboxylic acid-containing drugs.
   
 0.913
EPHX1
Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.
   
 0.912
LOC100686607
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 0.910
LOC100856068
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 0.910
CYP2A7
Uncharacterized protein; Belongs to the cytochrome P450 family.
  
 
0.905
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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