PAXIP1 protein (Canis lupus familiaris) - STRING interaction network

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Score

PAXIP1

PAX interacting protein 1. (1035 aa)

Predicted Functional Partners:

TP53BP1

0.944

RBBP5

0.929

ASH2L

0.913

NCOA6

0.906

RIF1

0.896

ATM

0.893

KDM6A

0.886

NBN

0.883

UIMC1

0.879

MRE11

0.866

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASH2L	KDM6A	ENSCAFP00000048057	ENSCAFP00000045122	ASH2 like, histone lysine methyltransferase complex subunit.	Lysine demethylase 6A.	0.977
ASH2L	NCOA6	ENSCAFP00000048057	ENSCAFP00000011257	ASH2 like, histone lysine methyltransferase complex subunit.	Nuclear receptor coactivator 6.	0.982
ASH2L	PAXIP1	ENSCAFP00000048057	ENSCAFP00000007562	ASH2 like, histone lysine methyltransferase complex subunit.	PAX interacting protein 1.	0.913
ASH2L	RBBP5	ENSCAFP00000048057	ENSCAFP00000043189	ASH2 like, histone lysine methyltransferase complex subunit.	RB binding protein 5, histone lysine methyltransferase complex subunit.	0.999
ASH2L	TP53BP1	ENSCAFP00000048057	ENSCAFP00000018569	ASH2 like, histone lysine methyltransferase complex subunit.	Tumor protein p53 binding protein 1.	0.727
ATM	MRE11	ENSCAFP00000035996	ENSCAFP00000006193	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.996
ATM	NBN	ENSCAFP00000035996	ENSCAFP00000037607	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nibrin.	0.997
ATM	PAXIP1	ENSCAFP00000035996	ENSCAFP00000007562	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX interacting protein 1.	0.893
ATM	RIF1	ENSCAFP00000035996	ENSCAFP00000008476	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication timing regulatory factor 1.	0.889
ATM	TP53BP1	ENSCAFP00000035996	ENSCAFP00000018569	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein p53 binding protein 1.	0.989
ATM	UIMC1	ENSCAFP00000035996	ENSCAFP00000024343	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ubiquitin interaction motif containing 1.	0.655
KDM6A	ASH2L	ENSCAFP00000045122	ENSCAFP00000048057	Lysine demethylase 6A.	ASH2 like, histone lysine methyltransferase complex subunit.	0.977
KDM6A	NCOA6	ENSCAFP00000045122	ENSCAFP00000011257	Lysine demethylase 6A.	Nuclear receptor coactivator 6.	0.989
KDM6A	PAXIP1	ENSCAFP00000045122	ENSCAFP00000007562	Lysine demethylase 6A.	PAX interacting protein 1.	0.886
KDM6A	RBBP5	ENSCAFP00000045122	ENSCAFP00000043189	Lysine demethylase 6A.	RB binding protein 5, histone lysine methyltransferase complex subunit.	0.976
MRE11	ATM	ENSCAFP00000006193	ENSCAFP00000035996	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.996
MRE11	NBN	ENSCAFP00000006193	ENSCAFP00000037607	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Nibrin.	0.999
MRE11	PAXIP1	ENSCAFP00000006193	ENSCAFP00000007562	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	PAX interacting protein 1.	0.866
MRE11	RIF1	ENSCAFP00000006193	ENSCAFP00000008476	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Replication timing regulatory factor 1.	0.725
MRE11	TP53BP1	ENSCAFP00000006193	ENSCAFP00000018569	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Tumor protein p53 binding protein 1.	0.944