STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (320 aa)    
Predicted Functional Partners:
HMGCR
3-hydroxy-3-methylglutaryl coenzyme A reductase.
   
 
 0.902
SCAP
SREBF chaperone.
   
 
 0.845
NPC1
NPC intracellular cholesterol transporter 1.
   
 
 0.723
CHAF1B
Chromatin assembly factor 1 subunit B.
   
 
 0.720
RNF145
Ring finger protein 145.
    
 
 0.707
AMFR
Autocrine motility factor receptor.
   
 
 0.688
HMGCS1
3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.683
DHCR24
24-dehydrocholesterol reductase.
   
  
 0.647
PTPRN2
Protein tyrosine phosphatase receptor type N2.
   
  
 0.622
FASN
Fatty acid synthase.
   
 
 0.600
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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