STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (659 aa)    
Predicted Functional Partners:
INPP5A
Inositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.
     
 0.927
INPP5J
Inositol polyphosphate-5-phosphatase J.
     
 0.921
INPP5K
Inositol polyphosphate-5-phosphatase K.
   
 
 0.917
MINPP1
Multiple inositol-polyphosphate phosphatase 1; Belongs to the histidine acid phosphatase family.
     
 0.915
J9NWQ5_CANLF
Uncharacterized protein; Belongs to the calmodulin family.
    
 0.913
ITPK1
Inositol-tetrakisphosphate 1-kinase.
   
 
 0.908
ITPKA
Kinase; Belongs to the inositol phosphokinase (IPK) family.
  
 
0.906
ITPKB
Kinase; Belongs to the inositol phosphokinase (IPK) family.
  
  
0.903
LRRC59
Leucine rich repeat containing 59.
   
  
 0.801
PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.
   
 
 0.713
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.