STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RHBDF2Inactive rhomboid protein 2; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. Belongs to the peptidase S54 family. (920 aa)    
Predicted Functional Partners:
FRMD8
FERM domain containing 8.
   
  
 0.672
UBE2O
Ubiquitin conjugating enzyme E2 O.
   
 
 0.654
IL17REL
Interleukin 17 receptor E like.
      
 0.649
CYGB
Cytoglobin; Belongs to the globin family.
 
 
  
 0.600
RASSF3
Ras association domain family member 3.
   
  
 0.578
METTL23
Uncharacterized protein.
    
 
 0.567
PRPSAP1
Phosphoribosyl pyrophosphate synthetase associated protein 1.
      
 0.563
TNIP3
TNFAIP3 interacting protein 3.
      
 0.561
ADAM17
Uncharacterized protein.
    
 
 0.549
AANAT
Arylalkylamine N-acetyltransferase.
   
  
 0.532
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (30%) [HD]