STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CST8Cystatin 8. (142 aa)    
Predicted Functional Partners:
GZF1
GDNF inducible zinc finger protein 1.
   
 
 0.866
ACSS1
Acetyl-coenzyme A synthetase.
      
 0.693
LOC485559
Cystatin domain-containing protein.
   
  
 0.661
LCN9
Lipocalin 9; Belongs to the calycin superfamily. Lipocalin family.
   
  
 0.636
NXT2
Nuclear transport factor 2 like export factor 2.
      
 0.577
ECSCR
Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2 (By similarity).
      
 0.554
RILPL1
Rab interacting lysosomal protein like 1.
      
 0.536
CCNB3
G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (By similarity).
      
 0.531
DEFB121
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.529
KAT6A
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
      
 0.527
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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