STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VHLVon Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity). (219 aa)    
Predicted Functional Partners:
CUL2
Cullin 2; Belongs to the cullin family.
   
 0.996
ELOB
Elongin B.
    
 0.995
HIF1A
Uncharacterized protein.
   
 0.995
ELOC
Elongin C; Belongs to the SKP1 family.
   
 0.993
RBX1
Ring-box 1.
    
 0.992
EPAS1
Endothelial PAS domain protein 1.
    
 0.988
HIF3A
Hypoxia inducible factor 3 subunit alpha.
    
 0.872
ENSCAFP00000054409
Skp1_POZ domain-containing protein.
   
 
 0.838
ENSCAFP00000060212
Uncharacterized protein.
   
 
 0.787
NEDD8
NEDD8 ubiquitin like modifier.
    
 0.783
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.