STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)    
Predicted Functional Partners:
ASAH2
Neutral ceramidase.
    
 0.982
CERS3
Ceramide synthase 3.
    
 0.980
ASAH1
N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family.
   
 
 0.979
SPHK1
Sphingosine kinase 1.
    
 0.958
CERS2
Ceramide synthase 2.
    
 0.948
CERS4
Ceramide synthase 4.
    
 0.948
DEGS2
Delta 4-desaturase, sphingolipid 2.
   
 
 0.943
PLPP2
Phospholipid phosphatase 2.
     
 0.941
SPHK2
Sphingosine kinase 2.
    
 0.940
CERS6
Ceramide synthase 6.
    
 0.939
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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