Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ULK4Unc-51 like kinase 4. (1274 aa)    
Predicted Functional Partners:
SUFU
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
 0.844
CCDC149
Coiled-coil domain containing 149.
      
 0.811
ARHGAP11A
Rho GTPase activating protein 11A.
      
 0.810
CHRNA2
Cholinergic receptor nicotinic alpha 2 subunit.
      
 0.802
CHRNA5
Cholinergic receptor nicotinic alpha 5 subunit.
      
 0.797
CHRNA9
Cholinergic receptor nicotinic alpha 9 subunit.
      
 0.737
IQCA1
IQ motif containing with AAA domain 1.
   
  
 0.698
SLC36A1
Solute carrier family 36 member 1.
      
 0.685
OTUD7A
OTU deubiquitinase 7A.
      
 0.611
ADGB
Androglobin; Belongs to the peptidase C2 family.
      
 0.605
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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