UCN3 protein (Canis lupus familiaris) - STRING interaction network

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Score

UCN3

Urocortin 3. (167 aa)

Predicted Functional Partners:

CRHR2

0.985

UCN

0.979

CRH

0.967

LOC610380

0.949

GCK

0.684

CRHBP

0.631

SST

0.628

SGTB

0.608

GHRL

0.593

MAPK15

0.592

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRH	CRHBP	ENSCAFP00000040748	ENSCAFP00000013633	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.821
CRH	CRHR2	ENSCAFP00000040748	ENSCAFP00000004610	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.995
CRH	GHRL	ENSCAFP00000040748	ENSCAFP00000007641	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	0.727
CRH	LOC610380	ENSCAFP00000040748	ENSCAFP00000020012	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.997
CRH	SST	ENSCAFP00000040748	ENSCAFP00000064277	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.	0.805
CRH	UCN	ENSCAFP00000040748	ENSCAFP00000031248	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Urocortin.	0.979
CRH	UCN3	ENSCAFP00000040748	ENSCAFP00000007854	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	Urocortin 3.	0.967
CRHBP	CRH	ENSCAFP00000013633	ENSCAFP00000040748	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	0.821
CRHBP	CRHR2	ENSCAFP00000013633	ENSCAFP00000004610	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	0.749
CRHBP	LOC610380	ENSCAFP00000013633	ENSCAFP00000020012	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.832
CRHBP	MAPK15	ENSCAFP00000013633	ENSCAFP00000044900	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Mitogen-activated protein kinase.	0.606
CRHBP	UCN	ENSCAFP00000013633	ENSCAFP00000031248	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Urocortin.	0.684
CRHBP	UCN3	ENSCAFP00000013633	ENSCAFP00000007854	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	Urocortin 3.	0.631
CRHR2	CRH	ENSCAFP00000004610	ENSCAFP00000040748	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.	0.995
CRHR2	CRHBP	ENSCAFP00000004610	ENSCAFP00000013633	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.749
CRHR2	LOC610380	ENSCAFP00000004610	ENSCAFP00000020012	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.881
CRHR2	UCN	ENSCAFP00000004610	ENSCAFP00000031248	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Urocortin.	0.995
CRHR2	UCN3	ENSCAFP00000004610	ENSCAFP00000007854	Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family.	Urocortin 3.	0.985
GCK	GHRL	ENSCAFP00000004364	ENSCAFP00000007641	Phosphotransferase.	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	0.521
GCK	SST	ENSCAFP00000004364	ENSCAFP00000064277	Phosphotransferase.	Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.	0.610