STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
    
 0.993
GRB2
Growth factor receptor bound protein 2.
    
 0.977
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.924
SPRY1
Sprouty RTK signaling antagonist 1.
  
0.776
CBLB
Cbl proto-oncogene B.
    
 
 0.772
ZDHHC17
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
    
   0.768
UBA52
Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]
     
  0.700
RPS27A
Ubiquitin-like domain-containing protein.
     
  0.700
PPP2CB
Serine/threonine-protein phosphatase.
    
  0.675
PPP2CA
Serine/threonine-protein phosphatase.
    
  0.675
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.