TMC6 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

TMC6

Transmembrane channel-like protein. (766 aa)

Predicted Functional Partners:

EFHB

0.721

KPNA6

0.660

DUSP27

0.653

LRFN4

0.652

VPS50

0.645

KCTD2

0.617

SYNGR2

0.609

CD300LG

0.608

SCLY

0.607

RAVER1

0.606

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD300LG	KCTD2	ENSCAFP00000042929	ENSCAFP00000007024	CD300 molecule like family member g.	Potassium channel tetramerization domain containing 2.	0.610
CD300LG	TMC6	ENSCAFP00000042929	ENSCAFP00000007873	CD300 molecule like family member g.	Transmembrane channel-like protein.	0.608
DUSP27	EFHB	ENSCAFP00000022900	ENSCAFP00000035923	Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	EF-hand domain family member B.	0.804
DUSP27	KPNA6	ENSCAFP00000022900	ENSCAFP00000015820	Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Importin subunit alpha; Functions in nuclear protein import.	0.612
DUSP27	LRFN4	ENSCAFP00000022900	ENSCAFP00000017440	Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Leucine rich repeat and fibronectin type III domain containing 4.	0.705
DUSP27	RAVER1	ENSCAFP00000022900	ENSCAFP00000059915	Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Uncharacterized protein.	0.709
DUSP27	SCLY	ENSCAFP00000022900	ENSCAFP00000046415	Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Selenocysteine lyase.	0.621
DUSP27	TMC6	ENSCAFP00000022900	ENSCAFP00000007873	Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	Transmembrane channel-like protein.	0.653
EFHB	DUSP27	ENSCAFP00000035923	ENSCAFP00000022900	EF-hand domain family member B.	Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.804
EFHB	KPNA6	ENSCAFP00000035923	ENSCAFP00000015820	EF-hand domain family member B.	Importin subunit alpha; Functions in nuclear protein import.	0.642
EFHB	LRFN4	ENSCAFP00000035923	ENSCAFP00000017440	EF-hand domain family member B.	Leucine rich repeat and fibronectin type III domain containing 4.	0.745
EFHB	RAVER1	ENSCAFP00000035923	ENSCAFP00000059915	EF-hand domain family member B.	Uncharacterized protein.	0.728
EFHB	SCLY	ENSCAFP00000035923	ENSCAFP00000046415	EF-hand domain family member B.	Selenocysteine lyase.	0.719
EFHB	TMC6	ENSCAFP00000035923	ENSCAFP00000007873	EF-hand domain family member B.	Transmembrane channel-like protein.	0.721
KCTD2	CD300LG	ENSCAFP00000007024	ENSCAFP00000042929	Potassium channel tetramerization domain containing 2.	CD300 molecule like family member g.	0.610
KCTD2	TMC6	ENSCAFP00000007024	ENSCAFP00000007873	Potassium channel tetramerization domain containing 2.	Transmembrane channel-like protein.	0.617
KPNA6	DUSP27	ENSCAFP00000015820	ENSCAFP00000022900	Importin subunit alpha; Functions in nuclear protein import.	Dual specificity phosphatase 27, atypical; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.612
KPNA6	EFHB	ENSCAFP00000015820	ENSCAFP00000035923	Importin subunit alpha; Functions in nuclear protein import.	EF-hand domain family member B.	0.642
KPNA6	LRFN4	ENSCAFP00000015820	ENSCAFP00000017440	Importin subunit alpha; Functions in nuclear protein import.	Leucine rich repeat and fibronectin type III domain containing 4.	0.698
KPNA6	RAVER1	ENSCAFP00000015820	ENSCAFP00000059915	Importin subunit alpha; Functions in nuclear protein import.	Uncharacterized protein.	0.687