AKR1C3 protein (Canis lupus familiaris) - STRING interaction network

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AKR1C3

Aldo_ket_red domain-containing protein. (311 aa)

Predicted Functional Partners:

SRD5A2

0.946

SRD5A1

0.946

HSD3B2

0.939

HPGDS

0.929

CYP2D15

0.910

CYP7A1

0.907

LOC482182

0.906

HSD17B7

0.903

HSD17B1

0.902

HSD17B2

0.901

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKR1C3	CYP2D15	ENSCAFP00000007901	ENSCAFP00000065572	Aldo_ket_red domain-containing protein.	Cytochrome P450 2D15; High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.	0.910
AKR1C3	CYP7A1	ENSCAFP00000007901	ENSCAFP00000045160	Aldo_ket_red domain-containing protein.	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family.	0.907
AKR1C3	HPGDS	ENSCAFP00000007901	ENSCAFP00000061205	Aldo_ket_red domain-containing protein.	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	0.929
AKR1C3	HSD17B1	ENSCAFP00000007901	ENSCAFP00000022032	Aldo_ket_red domain-containing protein.	Hydroxysteroid 17-beta dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.902
AKR1C3	HSD17B2	ENSCAFP00000007901	ENSCAFP00000029598	Aldo_ket_red domain-containing protein.	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.901
AKR1C3	HSD17B7	ENSCAFP00000007901	ENSCAFP00000065581	Aldo_ket_red domain-containing protein.	Hydroxysteroid 17-beta dehydrogenase 7.	0.903
AKR1C3	HSD3B2	ENSCAFP00000007901	ENSCAFP00000014770	Aldo_ket_red domain-containing protein.	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity).	0.939
AKR1C3	LOC482182	ENSCAFP00000007901	ENSCAFP00000064446	Aldo_ket_red domain-containing protein.	Sulfotransferase; Belongs to the sulfotransferase 1 family.	0.906
AKR1C3	SRD5A1	ENSCAFP00000007901	ENSCAFP00000051308	Aldo_ket_red domain-containing protein.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.946
AKR1C3	SRD5A2	ENSCAFP00000007901	ENSCAFP00000037968	Aldo_ket_red domain-containing protein.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.946
CYP2D15	AKR1C3	ENSCAFP00000065572	ENSCAFP00000007901	Cytochrome P450 2D15; High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.	Aldo_ket_red domain-containing protein.	0.910
CYP2D15	CYP7A1	ENSCAFP00000065572	ENSCAFP00000045160	Cytochrome P450 2D15; High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family.	0.898
CYP2D15	HPGDS	ENSCAFP00000065572	ENSCAFP00000061205	Cytochrome P450 2D15; High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	0.461
CYP2D15	HSD3B2	ENSCAFP00000065572	ENSCAFP00000014770	Cytochrome P450 2D15; High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity).	0.895
CYP7A1	AKR1C3	ENSCAFP00000045160	ENSCAFP00000007901	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family.	Aldo_ket_red domain-containing protein.	0.907
CYP7A1	CYP2D15	ENSCAFP00000045160	ENSCAFP00000065572	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family.	Cytochrome P450 2D15; High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.	0.898
CYP7A1	HSD17B7	ENSCAFP00000045160	ENSCAFP00000065581	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid 17-beta dehydrogenase 7.	0.653
CYP7A1	HSD3B2	ENSCAFP00000045160	ENSCAFP00000014770	Cytochrome P450 family 7 subfamily A member 1; Belongs to the cytochrome P450 family.	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity).	0.935
HPGDS	AKR1C3	ENSCAFP00000061205	ENSCAFP00000007901	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Aldo_ket_red domain-containing protein.	0.929
HPGDS	CYP2D15	ENSCAFP00000061205	ENSCAFP00000065572	Hematopoietic prostaglandin D synthase; Belongs to the GST superfamily.	Cytochrome P450 2D15; High activity for the hydroxylation of bunitrolol and imipramine; low activity on debrisoquine.	0.461