| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FZD1 | WIF1 | ENSCAFP00000002804 | ENSCAFP00000061273 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | WNT inhibitory factor 1. | 0.473 |
| FZD1 | WNT11 | ENSCAFP00000002804 | ENSCAFP00000007907 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.963 |
| FZD10 | WIF1 | ENSCAFP00000010143 | ENSCAFP00000061273 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | WNT inhibitory factor 1. | 0.627 |
| FZD10 | WNT11 | ENSCAFP00000010143 | ENSCAFP00000007907 | Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.966 |
| FZD3 | FZD4 | ENSCAFP00000012176 | ENSCAFP00000053452 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.646 |
| FZD3 | FZD5 | ENSCAFP00000012176 | ENSCAFP00000019956 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.585 |
| FZD3 | FZD6 | ENSCAFP00000012176 | ENSCAFP00000000924 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.577 |
| FZD3 | WNT11 | ENSCAFP00000012176 | ENSCAFP00000007907 | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.970 |
| FZD4 | FZD3 | ENSCAFP00000053452 | ENSCAFP00000012176 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.646 |
| FZD4 | FZD5 | ENSCAFP00000053452 | ENSCAFP00000019956 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.535 |
| FZD4 | FZD6 | ENSCAFP00000053452 | ENSCAFP00000000924 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.607 |
| FZD4 | WNT11 | ENSCAFP00000053452 | ENSCAFP00000007907 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.976 |
| FZD5 | FZD3 | ENSCAFP00000019956 | ENSCAFP00000012176 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.585 |
| FZD5 | FZD4 | ENSCAFP00000019956 | ENSCAFP00000053452 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.535 |
| FZD5 | FZD6 | ENSCAFP00000019956 | ENSCAFP00000000924 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.608 |
| FZD5 | WNT11 | ENSCAFP00000019956 | ENSCAFP00000007907 | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.959 |
| FZD6 | FZD3 | ENSCAFP00000000924 | ENSCAFP00000012176 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.577 |
| FZD6 | FZD4 | ENSCAFP00000000924 | ENSCAFP00000053452 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.607 |
| FZD6 | FZD5 | ENSCAFP00000000924 | ENSCAFP00000019956 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.608 |
| FZD6 | WNT11 | ENSCAFP00000000924 | ENSCAFP00000007907 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.982 |