DCT protein (Canis lupus familiaris) - STRING interaction network

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Score

DCT

Uncharacterized protein. (548 aa)

Predicted Functional Partners:

MLANA

0.952

TYR

0.908

MITF

0.848

MGRN1

0.802

AMACR

0.795

SLC24A5

0.790

KIT

0.782

ASIP

0.772

SOX10

0.717

OCA2

0.714

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMACR	ASIP	ENSCAFP00000059485	ENSCAFP00000034367	Solute carrier family 45 member 2.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	0.672
AMACR	DCT	ENSCAFP00000059485	ENSCAFP00000007942	Solute carrier family 45 member 2.	Uncharacterized protein.	0.795
AMACR	KIT	ENSCAFP00000059485	ENSCAFP00000003042	Solute carrier family 45 member 2.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.484
AMACR	MITF	ENSCAFP00000059485	ENSCAFP00000048192	Solute carrier family 45 member 2.	Melanocyte inducing transcription factor.	0.639
AMACR	MLANA	ENSCAFP00000059485	ENSCAFP00000001943	Solute carrier family 45 member 2.	Melan-A.	0.890
AMACR	OCA2	ENSCAFP00000059485	ENSCAFP00000014591	Solute carrier family 45 member 2.	OCA2 melanosomal transmembrane protein.	0.936
AMACR	SLC24A5	ENSCAFP00000059485	ENSCAFP00000053425	Solute carrier family 45 member 2.	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.965
AMACR	SOX10	ENSCAFP00000059485	ENSCAFP00000002067	Solute carrier family 45 member 2.	SRY-box transcription factor 10.	0.555
AMACR	TYR	ENSCAFP00000059485	ENSCAFP00000006504	Solute carrier family 45 member 2.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.917
ASIP	AMACR	ENSCAFP00000034367	ENSCAFP00000059485	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	Solute carrier family 45 member 2.	0.672
ASIP	DCT	ENSCAFP00000034367	ENSCAFP00000007942	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	Uncharacterized protein.	0.772
ASIP	KIT	ENSCAFP00000034367	ENSCAFP00000003042	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.718
ASIP	MGRN1	ENSCAFP00000034367	ENSCAFP00000066535	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	Mahogunin ring finger 1.	0.847
ASIP	MITF	ENSCAFP00000034367	ENSCAFP00000048192	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	Melanocyte inducing transcription factor.	0.813
ASIP	OCA2	ENSCAFP00000034367	ENSCAFP00000014591	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	OCA2 melanosomal transmembrane protein.	0.681
ASIP	SLC24A5	ENSCAFP00000034367	ENSCAFP00000053425	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.	0.652
ASIP	TYR	ENSCAFP00000034367	ENSCAFP00000006504	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.863
DCT	AMACR	ENSCAFP00000007942	ENSCAFP00000059485	Uncharacterized protein.	Solute carrier family 45 member 2.	0.795
DCT	ASIP	ENSCAFP00000007942	ENSCAFP00000034367	Uncharacterized protein.	Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).	0.772
DCT	KIT	ENSCAFP00000007942	ENSCAFP00000003042	Uncharacterized protein.	Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...]	0.782