Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SPTBN4Spectrin beta, non-erythrocytic 4. (844 aa)    
Predicted Functional Partners:
SPTBN4-2
Uncharacterized protein.
 
    
0.907
SPTAN1
Spectrin alpha, non-erythrocytic 1.
   
 0.853
ARFGEF1
ADP ribosylation factor guanine nucleotide exchange factor 1.
      
 0.810
SGSM3
Small G protein signaling modulator 3.
      
 0.796
BRPF1
Bromodomain and PHD finger containing 1.
   
  
 0.794
ARHGEF1
DH domain-containing protein.
      
 0.777
ADD2
Adducin 2.
   
 
 0.755
SPTA1
Spectrin alpha, erythrocytic 1.
   
 0.717
SPTBN2
Spectrin beta chain; Belongs to the spectrin family.
   
  0.702
ATP5MC2
ATP-synt_C domain-containing protein; Belongs to the ATPase C chain family.
      
 0.609
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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