PITRM1 protein (Canis lupus familiaris) - STRING interaction network

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Score

PITRM1

Pitrilysin metallopeptidase 1. (1035 aa)

Predicted Functional Partners:

APP

0.919

SLC46A3

0.712

APLP2

0.654

CPPED1

0.640

PDHA1

0.616

DLD

0.581

IDE

0.577

TOMM40

0.571

EPRS1

0.533

TTC29

0.530

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLP2	APP	ENSCAFP00000014894	ENSCAFP00000012583	Amyloid beta precursor like protein 2.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.572
APLP2	IDE	ENSCAFP00000014894	ENSCAFP00000011097	Amyloid beta precursor like protein 2.	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.621
APLP2	PITRM1	ENSCAFP00000014894	ENSCAFP00000008039	Amyloid beta precursor like protein 2.	Pitrilysin metallopeptidase 1.	0.654
APP	APLP2	ENSCAFP00000012583	ENSCAFP00000014894	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Amyloid beta precursor like protein 2.	0.572
APP	IDE	ENSCAFP00000012583	ENSCAFP00000011097	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Insulin degrading enzyme; Belongs to the peptidase M16 family.	0.966
APP	PITRM1	ENSCAFP00000012583	ENSCAFP00000008039	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Pitrilysin metallopeptidase 1.	0.919
APP	TOMM40	ENSCAFP00000012583	ENSCAFP00000006902	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Translocase of outer mitochondrial membrane 40.	0.565
CPPED1	PITRM1	ENSCAFP00000037318	ENSCAFP00000008039	Calcineurin like phosphoesterase domain containing 1.	Pitrilysin metallopeptidase 1.	0.640
CPPED1	SLC46A3	ENSCAFP00000037318	ENSCAFP00000009982	Calcineurin like phosphoesterase domain containing 1.	Solute carrier family 46 member 3.	0.756
DLD	PDHA1	ENSCAFP00000005721	ENSCAFP00000055957	Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...]	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
DLD	PITRM1	ENSCAFP00000005721	ENSCAFP00000008039	Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...]	Pitrilysin metallopeptidase 1.	0.581
EPRS1	PDHA1	ENSCAFP00000063801	ENSCAFP00000055957	Glutamyl-prolyl-tRNA synthetase.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.546
EPRS1	PITRM1	ENSCAFP00000063801	ENSCAFP00000008039	Glutamyl-prolyl-tRNA synthetase.	Pitrilysin metallopeptidase 1.	0.533
IDE	APLP2	ENSCAFP00000011097	ENSCAFP00000014894	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Amyloid beta precursor like protein 2.	0.621
IDE	APP	ENSCAFP00000011097	ENSCAFP00000012583	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.966
IDE	PITRM1	ENSCAFP00000011097	ENSCAFP00000008039	Insulin degrading enzyme; Belongs to the peptidase M16 family.	Pitrilysin metallopeptidase 1.	0.577
PDHA1	DLD	ENSCAFP00000055957	ENSCAFP00000005721	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT [...]	0.999
PDHA1	EPRS1	ENSCAFP00000055957	ENSCAFP00000063801	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Glutamyl-prolyl-tRNA synthetase.	0.546
PDHA1	PITRM1	ENSCAFP00000055957	ENSCAFP00000008039	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	Pitrilysin metallopeptidase 1.	0.616
PITRM1	APLP2	ENSCAFP00000008039	ENSCAFP00000014894	Pitrilysin metallopeptidase 1.	Amyloid beta precursor like protein 2.	0.654