STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MGME1Uncharacterized protein. (237 aa)    
Predicted Functional Partners:
ECSIT
ECSIT signalling integrator.
    
   0.826
REXO1
RNA exonuclease 1 homolog.
      
 0.774
MIPEP
Mitochondrial intermediate peptidase.
    
   0.747
DXO
Decapping exoribonuclease.
   
  
 0.696
C1H18orf54
Chromosome 1 C18orf54 homolog.
      
 0.652
PNPT1
Polyribonucleotide nucleotidyltransferase 1.
      
 0.622
COA7
Cytochrome c oxidase assembly factor 7 (putative).
      
 0.615
POLG2
DNA polymerase gamma 2, accessory subunit.
      
 0.604
FEN1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
  
 0.600
ZC3H12A
Zinc finger CCCH-type containing 12A.
      
 0.591
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.