RNF169 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RNF169

Ring finger protein 169. (712 aa)

Predicted Functional Partners:

DYRK1A

0.963

DCAF7

0.877

USP7

0.852

FBXO38

0.816

RNF168

0.816

RNF8

0.783

RPS16

0.767

TP53BP1

0.706

RAD18

0.703

BRCA1

0.703

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	RAD18	ENSCAFP00000048759	ENSCAFP00000008290	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RAD18 E3 ubiquitin protein ligase.	0.922
BRCA1	RNF168	ENSCAFP00000048759	ENSCAFP00000053641	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ring finger protein 168.	0.867
BRCA1	RNF169	ENSCAFP00000048759	ENSCAFP00000008167	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Ring finger protein 169.	0.703
BRCA1	RNF8	ENSCAFP00000048759	ENSCAFP00000053376	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.642
BRCA1	TP53BP1	ENSCAFP00000048759	ENSCAFP00000018569	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Tumor protein p53 binding protein 1.	0.985
DCAF7	DYRK1A	ENSCAFP00000019098	ENSCAFP00000014403	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 1A.	0.966
DCAF7	RNF168	ENSCAFP00000019098	ENSCAFP00000053641	DDB1 and CUL4 associated factor 7.	Ring finger protein 168.	0.605
DCAF7	RNF169	ENSCAFP00000019098	ENSCAFP00000008167	DDB1 and CUL4 associated factor 7.	Ring finger protein 169.	0.877
DCAF7	RPS16	ENSCAFP00000019098	ENSCAFP00000066023	DDB1 and CUL4 associated factor 7.	Dual specificity tyrosine phosphorylation regulated kinase 1B.	0.962
DCAF7	TP53BP1	ENSCAFP00000019098	ENSCAFP00000018569	DDB1 and CUL4 associated factor 7.	Tumor protein p53 binding protein 1.	0.464
DYRK1A	DCAF7	ENSCAFP00000014403	ENSCAFP00000019098	Dual specificity tyrosine phosphorylation regulated kinase 1A.	DDB1 and CUL4 associated factor 7.	0.966
DYRK1A	RNF168	ENSCAFP00000014403	ENSCAFP00000053641	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Ring finger protein 168.	0.598
DYRK1A	RNF169	ENSCAFP00000014403	ENSCAFP00000008167	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Ring finger protein 169.	0.963
DYRK1A	RPS16	ENSCAFP00000014403	ENSCAFP00000066023	Dual specificity tyrosine phosphorylation regulated kinase 1A.	Dual specificity tyrosine phosphorylation regulated kinase 1B.	0.875
FBXO38	RAD18	ENSCAFP00000027129	ENSCAFP00000008290	F-box protein 38.	RAD18 E3 ubiquitin protein ligase.	0.406
FBXO38	RNF168	ENSCAFP00000027129	ENSCAFP00000053641	F-box protein 38.	Ring finger protein 168.	0.407
FBXO38	RNF169	ENSCAFP00000027129	ENSCAFP00000008167	F-box protein 38.	Ring finger protein 169.	0.816
FBXO38	USP7	ENSCAFP00000027129	ENSCAFP00000028037	F-box protein 38.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.879
RAD18	BRCA1	ENSCAFP00000008290	ENSCAFP00000048759	RAD18 E3 ubiquitin protein ligase.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.922
RAD18	FBXO38	ENSCAFP00000008290	ENSCAFP00000027129	RAD18 E3 ubiquitin protein ligase.	F-box protein 38.	0.406