STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RNF169Ring finger protein 169. (712 aa)    
Predicted Functional Partners:
RNF8
E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
   
  
 0.924
USP7
Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.
    
 
 0.900
RNF168
Ring finger protein 168.
   
 
0.802
MCMBP
Uncharacterized protein.
      
 0.789
DYRK1A
Dual specificity tyrosine phosphorylation regulated kinase 1A.
   
 
 0.765
RAD18
RAD18 E3 ubiquitin protein ligase.
   
  
 0.707
FBXO38
F-box protein 38.
    
 
 0.699
ZNF644
Zinc finger protein 644.
   
  
 0.699
SLF1
SMC5-SMC6 complex localization factor 1.
   
 
 0.692
L3MBTL2
L3MBTL histone methyl-lysine binding protein 2.
   
  
 0.640
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.