STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARHGAP15Rho GTPase activating protein 15. (471 aa)    
Predicted Functional Partners:
ARHGAP9
SH3 domain-containing protein.
 
 
  
 0.917
F1PA32_CANLF
WW domain-containing protein.
 
 
  
 0.907
GTDC1
Glycosyltransferase like domain containing 1.
   
  
 0.833
RAC1
Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]
   
 0.664
ARL4C
ADP ribosylation factor like GTPase 4C; Belongs to the small GTPase superfamily. Arf family.
    
 
 0.604
BNIPL
BCL2 interacting protein like.
   
  
 0.588
PTPRC
Protein tyrosine phosphatase receptor type C.
   
  
 0.587
MMADHC
Metabolism of cobalamin associated D.
      
 0.584
ARHGEF10L
Rho guanine nucleotide exchange factor 10 like.
      
 0.575
SCNM1
Sodium channel modifier 1.
      
 0.572
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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