STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHRDL2Chordin like 2. (430 aa)    
Predicted Functional Partners:
BMP7
Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity).
    
 
 0.720
TWSG1
Twisted gastrulation BMP signaling modulator 1.
      
 0.665
SLC25A48
Solute carrier family 25 member 48; Belongs to the mitochondrial carrier (TC 2.A.29) family.
    
 
 0.620
CLSTN2
Calsyntenin 2.
   
 
 0.568
FSTL3
Follistatin like 3.
    
 
 0.563
PTCHD4
Patched domain containing 4.
      
 0.562
CRLF1
Cytokine receptor like factor 1.
      
 0.561
GFRA2
GDNF family receptor alpha 2.
   
  
 0.560
BMP6
Bone morphogenetic protein 6.
    
 
 0.545
CHRD
Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.
   
  
0.542
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (16%) [HD]