STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ARHGEF40Rho guanine nucleotide exchange factor 40. (1624 aa)    
Predicted Functional Partners:
RAPH1
Uncharacterized protein.
      
 0.562
RABIF
RAB interacting factor.
      
 0.533
SORBS1
Sorbin and SH3 domain containing 1.
   
 
 0.529
ARHGEF2
Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...]
   
  
 0.503
KRT18
IF rod domain-containing protein; Belongs to the intermediate filament family.
    
 
 0.495
MTA1
Metastasis associated 1.
      
 0.466
MBNL2
Muscleblind like splicing regulator 2.
      
 0.465
MBNL3
Muscleblind like splicing regulator 3.
      
 0.427
ADD3
Adducin 3.
      
 0.426
MBNL1
Muscleblind like splicing regulator 1.
      
 0.426
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.