STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)    
Predicted Functional Partners:
KCNQ1
Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family.
   
 0.995
KCNK5
Potassium two pore domain channel subfamily K member 5; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
     
 0.933
KCNN4
Potassium calcium-activated channel subfamily N member 4.
   
 
 0.924
KCNJ13
Potassium voltage-gated channel subfamily J member 13.
     
 0.913
KCNE2
Potassium voltage-gated channel subfamily E regulatory subunit 2.
      
 0.894
KCNE4
Potassium voltage-gated channel subfamily E regulatory subunit 4.
      
 0.894
KCNH2
Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.
     
 0.840
SCN1B
Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A.
      
 0.825
KCNE5
Potassium voltage-gated channel subfamily E regulatory subunit 5.
      
 0.819
KCNQ4
Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family.
   
 0.803
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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