STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AZI25-azacytidine induced 2. (393 aa)    
Predicted Functional Partners:
TBK1
TANK binding kinase 1.
   
 
 0.965
TANK
TRAF family member associated NFKB activator.
   
 
 0.945
CALCOCO2
Calcium binding and coiled-coil domain 2.
    
 
 0.935
TNF
Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]
    
   0.926
IKBKG
Inhibitor of nuclear factor kappa B kinase regulatory subunit gamma.
     
 0.905
TMEM51
Transmembrane protein 51.
      
 0.892
NDUFAF6
NADH:ubiquinone oxidoreductase complex assembly factor 6.
      
 0.885
TBKBP1
TBK1 binding protein 1.
     
  0.881
IKBKE
Inhibitor of nuclear factor kappa B kinase subunit epsilon.
   
 
 0.860
BLVRB
Biliverdin reductase B.
      
 0.825
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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