RAD18 protein (Canis lupus familiaris) - STRING interaction network

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RAD18

RAD18 E3 ubiquitin protein ligase. (503 aa)

Predicted Functional Partners:

PCNA

0.995

POLH

0.968

SHPRH

0.960

HLTF

0.954

FANCD2

0.945

FANCM

0.940

RAD52

0.938

SLF1

0.934

UBE2B

0.926

BRCA1

0.922

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	FANCD2	ENSCAFP00000048759	ENSCAFP00000040012	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	FA complementation group D2.	0.986
BRCA1	FANCM	ENSCAFP00000048759	ENSCAFP00000041513	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	FA complementation group M.	0.863
BRCA1	HLTF	ENSCAFP00000048759	ENSCAFP00000012193	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Helicase like transcription factor.	0.636
BRCA1	PCNA	ENSCAFP00000048759	ENSCAFP00000009045	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.719
BRCA1	POLH	ENSCAFP00000048759	ENSCAFP00000002810	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA polymerase eta.	0.451
BRCA1	RAD18	ENSCAFP00000048759	ENSCAFP00000008290	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RAD18 E3 ubiquitin protein ligase.	0.922
BRCA1	RAD52	ENSCAFP00000048759	ENSCAFP00000023275	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RAD52 homolog, DNA repair protein.	0.811
BRCA1	SLF1	ENSCAFP00000048759	ENSCAFP00000011873	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	SMC5-SMC6 complex localization factor 1.	0.629
FANCD2	BRCA1	ENSCAFP00000040012	ENSCAFP00000048759	FA complementation group D2.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.986
FANCD2	FANCM	ENSCAFP00000040012	ENSCAFP00000041513	FA complementation group D2.	FA complementation group M.	0.998
FANCD2	HLTF	ENSCAFP00000040012	ENSCAFP00000012193	FA complementation group D2.	Helicase like transcription factor.	0.771
FANCD2	PCNA	ENSCAFP00000040012	ENSCAFP00000009045	FA complementation group D2.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.891
FANCD2	POLH	ENSCAFP00000040012	ENSCAFP00000002810	FA complementation group D2.	DNA polymerase eta.	0.483
FANCD2	RAD18	ENSCAFP00000040012	ENSCAFP00000008290	FA complementation group D2.	RAD18 E3 ubiquitin protein ligase.	0.945
FANCD2	RAD52	ENSCAFP00000040012	ENSCAFP00000023275	FA complementation group D2.	RAD52 homolog, DNA repair protein.	0.618
FANCD2	SLF1	ENSCAFP00000040012	ENSCAFP00000011873	FA complementation group D2.	SMC5-SMC6 complex localization factor 1.	0.415
FANCM	BRCA1	ENSCAFP00000041513	ENSCAFP00000048759	FA complementation group M.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.863
FANCM	FANCD2	ENSCAFP00000041513	ENSCAFP00000040012	FA complementation group M.	FA complementation group D2.	0.998
FANCM	HLTF	ENSCAFP00000041513	ENSCAFP00000012193	FA complementation group M.	Helicase like transcription factor.	0.864
FANCM	PCNA	ENSCAFP00000041513	ENSCAFP00000009045	FA complementation group M.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.948