STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
E2REW2_CANLFUncharacterized protein. (196 aa)    
Predicted Functional Partners:
IFNLR1
Interferon lambda receptor 1.
   
 
 0.791
IL10RB
Interleukin 10 receptor subunit beta.
    
 
 0.700
ISG15
ISG15 ubiquitin like modifier.
   
 
 0.509
LOC612539
Uncharacterized protein.
  
 
0.486
IL29L
Interferon lambda.
  
 
0.486
IFNG
Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.
  
   
 0.483
IL17REL
Interleukin 17 receptor E like.
      
 0.478
LOC609830
Uncharacterized protein.
    
 
 0.451
IFNAR1
Uncharacterized protein.
    
 
 0.451
BCLAF3
BCLAF1 and THRAP3 family member 3.
  
     0.413
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.