RIF1 protein (Canis lupus familiaris) - STRING interaction network

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[Homology]

Score

RIF1

Replication timing regulatory factor 1. (2549 aa)

Predicted Functional Partners:

TP53BP1

0.934

BLM

0.898

PAXIP1

0.896

ATM

0.889

ASF1A

0.802

RNF168

0.791

BARD1

0.777

SBNO1

0.745

SHLD2

0.741

ASTE1

0.734

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASF1A	BLM	ENSCAFP00000001339	ENSCAFP00000018251	Anti-silencing function 1A histone chaperone.	BLM RecQ like helicase.	0.656
ASF1A	RIF1	ENSCAFP00000001339	ENSCAFP00000008476	Anti-silencing function 1A histone chaperone.	Replication timing regulatory factor 1.	0.802
ASTE1	RIF1	ENSCAFP00000009160	ENSCAFP00000008476	Asteroid homolog 1.	Replication timing regulatory factor 1.	0.734
ASTE1	SHLD2	ENSCAFP00000009160	ENSCAFP00000051714	Asteroid homolog 1.	Shieldin complex subunit 2.	0.489
ASTE1	TP53BP1	ENSCAFP00000009160	ENSCAFP00000018569	Asteroid homolog 1.	Tumor protein p53 binding protein 1.	0.594
ATM	BARD1	ENSCAFP00000035996	ENSCAFP00000021054	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA1 associated RING domain 1.	0.953
ATM	BLM	ENSCAFP00000035996	ENSCAFP00000018251	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BLM RecQ like helicase.	0.943
ATM	PAXIP1	ENSCAFP00000035996	ENSCAFP00000007562	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PAX interacting protein 1.	0.893
ATM	RIF1	ENSCAFP00000035996	ENSCAFP00000008476	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication timing regulatory factor 1.	0.889
ATM	RNF168	ENSCAFP00000035996	ENSCAFP00000053641	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Ring finger protein 168.	0.807
ATM	TP53BP1	ENSCAFP00000035996	ENSCAFP00000018569	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tumor protein p53 binding protein 1.	0.989
BARD1	ATM	ENSCAFP00000021054	ENSCAFP00000035996	BRCA1 associated RING domain 1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.953
BARD1	BLM	ENSCAFP00000021054	ENSCAFP00000018251	BRCA1 associated RING domain 1.	BLM RecQ like helicase.	0.838
BARD1	PAXIP1	ENSCAFP00000021054	ENSCAFP00000007562	BRCA1 associated RING domain 1.	PAX interacting protein 1.	0.823
BARD1	RIF1	ENSCAFP00000021054	ENSCAFP00000008476	BRCA1 associated RING domain 1.	Replication timing regulatory factor 1.	0.777
BARD1	RNF168	ENSCAFP00000021054	ENSCAFP00000053641	BRCA1 associated RING domain 1.	Ring finger protein 168.	0.805
BARD1	SHLD2	ENSCAFP00000021054	ENSCAFP00000051714	BRCA1 associated RING domain 1.	Shieldin complex subunit 2.	0.423
BARD1	TP53BP1	ENSCAFP00000021054	ENSCAFP00000018569	BRCA1 associated RING domain 1.	Tumor protein p53 binding protein 1.	0.856
BLM	ASF1A	ENSCAFP00000018251	ENSCAFP00000001339	BLM RecQ like helicase.	Anti-silencing function 1A histone chaperone.	0.656
BLM	ATM	ENSCAFP00000018251	ENSCAFP00000035996	BLM RecQ like helicase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.943