STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ARAP1ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1. (1388 aa)    
Predicted Functional Partners:
SH3KBP1
SH3 domain containing kinase binding protein 1.
   
 
 0.702
PPM1E
Protein phosphatase, Mg2+/Mn2+ dependent 1E.
   
  
 0.642
EHBP1
EH domain binding protein 1.
   
  
 0.635
ARFIP2
ADP ribosylation factor interacting protein 2.
   
  
 0.608
RHOA
Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...]
   
 0.565
FBXO8
F-box protein 8.
      
 0.561
ARF5
ADP ribosylation factor 5; Belongs to the small GTPase superfamily. Arf family.
    
 
 0.536
CHTOP
Chromatin target of PRMT1.
      
 0.523
PLEK2
Pleckstrin 2.
      
 0.521
MTREX
Mtr4 exosome RNA helicase.
      
 0.515
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.