NGLY1 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NGLY1

N-glycanase 1. (655 aa)

Predicted Functional Partners:

RAD23B

0.989

VCP

0.954

AMFR

0.924

NSFL1C

0.902

DERL1

0.894

RAD23A

0.865

MAN2C1

0.862

UBXN1

0.857

TMEM259

0.833

ERMP1

0.817

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMFR	DERL1	ENSCAFP00000013489	ENSCAFP00000001384	Autocrine motility factor receptor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.982
AMFR	NGLY1	ENSCAFP00000013489	ENSCAFP00000008496	Autocrine motility factor receptor.	N-glycanase 1.	0.924
AMFR	RAD23B	ENSCAFP00000013489	ENSCAFP00000004125	Autocrine motility factor receptor.	RAD23 homolog B, nucleotide excision repair protein.	0.848
AMFR	UBXN1	ENSCAFP00000013489	ENSCAFP00000037281	Autocrine motility factor receptor.	UBX domain protein 1.	0.938
AMFR	VCP	ENSCAFP00000013489	ENSCAFP00000002927	Autocrine motility factor receptor.	Valosin containing protein; Belongs to the AAA ATPase family.	0.980
DERL1	AMFR	ENSCAFP00000001384	ENSCAFP00000013489	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Autocrine motility factor receptor.	0.982
DERL1	NGLY1	ENSCAFP00000001384	ENSCAFP00000008496	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	N-glycanase 1.	0.894
DERL1	NSFL1C	ENSCAFP00000001384	ENSCAFP00000010130	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	NSFL1 cofactor.	0.728
DERL1	RAD23B	ENSCAFP00000001384	ENSCAFP00000004125	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	RAD23 homolog B, nucleotide excision repair protein.	0.832
DERL1	UBXN1	ENSCAFP00000001384	ENSCAFP00000037281	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	UBX domain protein 1.	0.899
DERL1	VCP	ENSCAFP00000001384	ENSCAFP00000002927	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Valosin containing protein; Belongs to the AAA ATPase family.	0.984
ERMP1	NGLY1	ENSCAFP00000064488	ENSCAFP00000008496	Endoplasmic reticulum metallopeptidase 1.	N-glycanase 1.	0.817
ERMP1	NSFL1C	ENSCAFP00000064488	ENSCAFP00000010130	Endoplasmic reticulum metallopeptidase 1.	NSFL1 cofactor.	0.597
ERMP1	TMEM259	ENSCAFP00000064488	ENSCAFP00000041131	Endoplasmic reticulum metallopeptidase 1.	Transmembrane protein 259.	0.776
MAN2C1	NGLY1	ENSCAFP00000046556	ENSCAFP00000008496	Mannosidase alpha class 2C member 1.	N-glycanase 1.	0.862
NGLY1	AMFR	ENSCAFP00000008496	ENSCAFP00000013489	N-glycanase 1.	Autocrine motility factor receptor.	0.924
NGLY1	DERL1	ENSCAFP00000008496	ENSCAFP00000001384	N-glycanase 1.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.894
NGLY1	ERMP1	ENSCAFP00000008496	ENSCAFP00000064488	N-glycanase 1.	Endoplasmic reticulum metallopeptidase 1.	0.817
NGLY1	MAN2C1	ENSCAFP00000008496	ENSCAFP00000046556	N-glycanase 1.	Mannosidase alpha class 2C member 1.	0.862
NGLY1	NSFL1C	ENSCAFP00000008496	ENSCAFP00000010130	N-glycanase 1.	NSFL1 cofactor.	0.902