PAK5 protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

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[Homology]

Score

PAK5

Non-specific serine/threonine protein kinase. (719 aa)

Predicted Functional Partners:

CDC42-2

0.969

ARHGEF6

0.944

ARHGEF7

0.939

NCK2

0.937

NCK1

0.937

RAC2

0.936

RAC3

0.936

GNG12

0.916

LIMK1

0.914

MAP2K1

0.914

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGEF6	ARHGEF7	ENSCAFP00000057862	ENSCAFP00000061674	Rac/Cdc42 guanine nucleotide exchange factor 6.	Rho guanine nucleotide exchange factor 7.	0.927
ARHGEF6	CDC42-2	ENSCAFP00000057862	ENSCAFP00000060180	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.554
ARHGEF6	GNG12	ENSCAFP00000057862	ENSCAFP00000041436	Rac/Cdc42 guanine nucleotide exchange factor 6.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.514
ARHGEF6	NCK1	ENSCAFP00000057862	ENSCAFP00000011072	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cytoplasmic protein.	0.414
ARHGEF6	NCK2	ENSCAFP00000057862	ENSCAFP00000003087	Rac/Cdc42 guanine nucleotide exchange factor 6.	Cytoplasmic protein.	0.412
ARHGEF6	PAK5	ENSCAFP00000057862	ENSCAFP00000008503	Rac/Cdc42 guanine nucleotide exchange factor 6.	Non-specific serine/threonine protein kinase.	0.944
ARHGEF6	RAC2	ENSCAFP00000057862	ENSCAFP00000002174	Rac/Cdc42 guanine nucleotide exchange factor 6.	Rac family small GTPase 2.	0.936
ARHGEF6	RAC3	ENSCAFP00000057862	ENSCAFP00000008868	Rac/Cdc42 guanine nucleotide exchange factor 6.	Uncharacterized protein.	0.936
ARHGEF7	ARHGEF6	ENSCAFP00000061674	ENSCAFP00000057862	Rho guanine nucleotide exchange factor 7.	Rac/Cdc42 guanine nucleotide exchange factor 6.	0.927
ARHGEF7	CDC42-2	ENSCAFP00000061674	ENSCAFP00000060180	Rho guanine nucleotide exchange factor 7.	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	0.945
ARHGEF7	NCK1	ENSCAFP00000061674	ENSCAFP00000011072	Rho guanine nucleotide exchange factor 7.	Cytoplasmic protein.	0.639
ARHGEF7	NCK2	ENSCAFP00000061674	ENSCAFP00000003087	Rho guanine nucleotide exchange factor 7.	Cytoplasmic protein.	0.632
ARHGEF7	PAK5	ENSCAFP00000061674	ENSCAFP00000008503	Rho guanine nucleotide exchange factor 7.	Non-specific serine/threonine protein kinase.	0.939
ARHGEF7	RAC2	ENSCAFP00000061674	ENSCAFP00000002174	Rho guanine nucleotide exchange factor 7.	Rac family small GTPase 2.	0.937
ARHGEF7	RAC3	ENSCAFP00000061674	ENSCAFP00000008868	Rho guanine nucleotide exchange factor 7.	Uncharacterized protein.	0.936
CDC42-2	ARHGEF6	ENSCAFP00000060180	ENSCAFP00000057862	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rac/Cdc42 guanine nucleotide exchange factor 6.	0.554
CDC42-2	ARHGEF7	ENSCAFP00000060180	ENSCAFP00000061674	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Rho guanine nucleotide exchange factor 7.	0.945
CDC42-2	LIMK1	ENSCAFP00000060180	ENSCAFP00000018366	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	LIM domain kinase 1.	0.512
CDC42-2	NCK1	ENSCAFP00000060180	ENSCAFP00000011072	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Cytoplasmic protein.	0.445
CDC42-2	PAK5	ENSCAFP00000060180	ENSCAFP00000008503	Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]	Non-specific serine/threonine protein kinase.	0.969