STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DNAJC18DnaJ heat shock protein family (Hsp40) member C18. (368 aa)    
Predicted Functional Partners:
DNAJB2
DnaJ heat shock protein family (Hsp40) member B2.
  
 
 0.861
HSPA9
Stress-70 protein, mitochondrial; Belongs to the heat shock protein 70 family.
  
 0.808
FAM118A
Family with sequence similarity 118 member A.
    
 
 0.736
HSPA5
Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.
  
 0.731
HSPA1
Heat shock 70 kDa protein 1; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP [...]
  
 0.665
LETM2
Leucine zipper and EF-hand containing transmembrane protein 2.
   
 
 0.660
TMEM39B
Transmembrane protein 39B.
      
 0.647
HSPH1
Heat shock protein family H (Hsp110) member 1.
  
 0.639
HSPA14
Heat shock protein family A (Hsp70) member 14; Belongs to the heat shock protein 70 family.
  
 0.631
HSPA13
Heat shock protein family A (Hsp70) member 13.
  
 0.627
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.